Molecular epidemiology

The characterisation of microbial population diversity with sequencing is an active field of research in Microb’UP

Phylogenetic tree of Escherichia coli from Denamur et al Nature Review Microbiology 2021

With the democratization of sequencing technologies, genomics has become a key element of the characterization of microbes and infectious diseases. Molecular epidemiology, with the study of a rising number of samples is offering snapshots of the diversity found within species. The benefit of full genome sequences is multiple. First, it allows fine scale analysis of the species phylogenies that are sometime not resolved for some microbes. Second, it allows to track the evolutionary dynamics occurring within species. At large scale, these dynamics are well illustrated with the propagation of a succession of SarsCov2 variant or with the spread of antibiotic resistance among bacterial species. But, full genome sequencing can also offer a high enough resolution to tackle viral or bacterial dynamics within a hospital or through a chain of contamination. Third, access to the full genome gives access to the functional elements of these microbes and can help identify genes or alleles associated with some clone successes, from antibiotic resistance or virulence genes, to patho-adaptative mutations.

 With a vast number of teams with members directly involved in hospital virology, bacteriology and parasitology laboratory, Microb’UP network has access to a vast number of strains that are sequenced and studied in depth with the molecular epidemiology approach. On organisms ranging from HIV to Escherichia coli or sordariales.  Modelers are also present in the Microb’UP to integrate these data and make inferences about the evolutionary processes at play.



Webinar, 21st March 2024, 11:00 am

Webinar, 21st March 2024, 11:00 am

Host Laboratory : Maude Guillier (IBPC, Paris ; Chase BEISEL, Helmholtz Institute for RNA-based Infection Research, Würzburg, Germany: Harnessing the RNA biology of CRISPR-Cas systems Of the many examples of bacterial regulatory...