Sébastien Léon
Institut Jacques Monod
Membrane trafficking, ubiquitin and signaling
Website: https://www.ijm.fr/research-topics/research-groups/leon-lab-va/?lang=en
ORCID: 0000-0002-2536-8595
Twitter: @SebLeon5
Our team seeks to determine the adaptation strategies of cells to nutritional stresses, such as nutrient deficiencies or inhibition of metabolism. Our work is at the intersection of cell biology, cell signaling and metabolism, using the yeast Saccharomyces cerevisiae as a model.
We have many tools and expertise to perform experiments in the field of protein localization, post-translational modifications, interactions, proteomics, genetic screens (including a RoToR Robot by Singer and several genome-wide collections) etc.
Top 5 publications
1. Laussel C, Albanèse V, García-Rodríguez FJ, Ballin A, Defenouillère Q, Léon S (2022)
2-deoxyglucose inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity.
bioRxiv 2022.03.29.486183; doi: https://doi.org/10.1101/2022.03.29.486183
2. Ivashov V, Zimmer J, Schwabl S, Kahlhofer J, Weys S, Gstir R, Jakschitz T, Kremser L, Bonn GK, Lindner H, Huber LA, Leon S, Schmidt O, Teis D.
Complementary alpha-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids.
eLife. 2020;9. doi: 10.7554/eLife.58246. PubMed PMID: 32744498.
3. Defenouillėre Q, Verraes A, Laussel C, Friedrich A, Schacherer J, Leon S.
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose.
Sci Signal. 2019;12(597):aaw8000. doi: 10.1126/scisignal.aaw8000. PubMed PMID: 31481524.
4. Hovsepian J, Albanese V, Becuwe M, Ivashov V, Teis D, Leon S.
The yeast arrestin-related protein Bul1 is a novel actor of glucose-induced endocytosis.
Mol Biol Cell. 2018;29(9):1012-20. doi: 10.1091/mbc.E17-07-0466. PubMed PMID: 29514933; PMCID: PMC5921569.
5. Hovsepian J, Defenouillere Q, Albanese V, Vachova L, Garcia C, Palkova Z, Leon S.
Multilevel regulation of an alpha-arrestin by glucose depletion controls hexose transporter endocytosis.
J Cell Biol. 2017;216(6):1811-31. Epub 2017/05/05. doi: 10.1083/jcb.201610094. PubMed PMID: 28468835; PMCID: PMC5461024.
Dernières publications sur HAL :
- [hal-04795002] Ubiquiton—An inducible, linkage-specific polyubiquitylation toolby ano.nymous@ccsd.cnrs.fr.invalid (Christian Renz) on 21 November 2024 at 10h38
The posttranslational modifier ubiquitin regulates most cellular processes. Its ability to form polymeric chains of distinct linkages is key to its […]
- [hal-04747036] Direct observation of fluorescent proteins in gels: a rapid cost-efficient, and quantitative alternative to...by ano.nymous@ccsd.cnrs.fr.invalid (Matthieu Sanial) on 21 October 2024 at 18h04
Abstract The discovery of Green Fluorescent Protein (GFP) and its derivatives has revolutionized cell biology. These fluorescent proteins (FPs) have […]
- [hal-03843268] Endocytosis and stress: From mechanisms to cellular physiologyby ano.nymous@ccsd.cnrs.fr.invalid (Sébastien Léon) on 22 November 2022 at 11h56
This issue presents a series of articles and reviews on the theme "Endocytosis and stress". The purpose of this issue was to cover various aspects of […]
- [hal-03865336] 2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis,...by ano.nymous@ccsd.cnrs.fr.invalid (Clotilde Laussel) on 22 November 2022 at 11h33
Abstract 2-deoxyglucose is a glucose analog that impacts many aspects of cellular physiology. After its uptake and its phosphorylation into […]