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Marc Lecuit

Institut Pasteur

Biology of Infection

marc.lecuit@pasteur.fr

Website: https://research.pasteur.fr/en/team/biology-of-infection/
ORCID: 0000-0002-4491-1063
Twitter: @BIUPasteur

Systemic infections result from the invasion of hosts by microbial pathogens. A critical pathogenic determinant of microbes is their capacity to translocate from the external environment into the host across mucosal barriers, disseminate systemically and reach protected tissues such as the central nervous system and the fetus. Our research is focused on understanding the molecular mechanisms underlying the ability of microbes to target specifically host cells, cross mucosal, blood-brain and placental barriers, disseminate systemically and within tissues, as well as host responses to infection.

 

Top 5 publications

1. Maudet C, Kheloufi M, Levallois S, Gaillard J, Huang L, Gaultier C, Tsai YH, Disson O, Lecuit M
Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence
Nature 2022, 603 (7903), 900-906

2. Moura A, Lefrancq N, Leclercq A, Wirth T, Borges V, Gilpin B, Dallman TJ, Frey J, Franz E, Nielsen EM, Thomas J, Pightling A, Howden BP, Tarr CL, Gerner-Smidt P, Cauchemez S, Salje H, Brisse S, Lecuit M
Emergence and global spread of Listeria monocytogenes main clinical clonal complex
Science Advances 2021 Dec 3;7(49):eabj9805

3. Hafner L, Pichon M, Burucoa C, Moura A, Garcia-Garcera M, Lecuit M
Listeria monocytogenes faecal carriage is common and depends on the gut microbiota
Nature Communications 2021 Nov 24;12(1):6826

4. Meertens L, Lamine Hafirassou M, Couderc T, Bonnet-Madin L, Kril V, Kümmererr B, Labeau A, Brugier A, Simon-Loriere E, Burlaud Gaillard J, Doyen C, Pezzi L, Goupil T, Rafasse S, Vidalain PO, Bertrand Legout A, Gueneau L, Juntas-Morales R, Ben Yaou R, Bonne G, de Lamballerie X, Benkirane M, Roingeard P, Delaugerre C, Lecuit M, Amara A
FHL1A is a major host factor for chikungunya virus infection
Nature 2019 574:259–263

5. Buchrieser J, Degrelle SA, Couderc T, Nevers Q, Disson O, Manet C, Donahue DA, Porrot F, Hillion KH, Perthame E, Arroyo MV, Souquere S, Ruigrok K, Dupressoir A, Heidmann T, Montagutelli X, Fournier T*, Lecuit M*, Schwartz O*
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise
Science 2019 365 (6449), 176-180

 

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