Jérôme Estaquier

ORCID: 0000-0002-9432-8044 
Twitter: @EstaquierJ

The group led by Dr. Estaquier at the INSERM U1124 (Paris) and at Laval University (Quebec) is analyzing the mechanisms of programmed cell death (PCD) in the context of host-pathogen interactions. He published more than 160 manuscripts. Thus, the specificity of his team is an upstream research aimed at clarifying the biochemical and molecular mechanisms of PCD associated with immune responses and analyzing these mechanisms in vivo by using as model of human diseases non-human primates. Among the contributions, the team demonstrated the importance of apoptosis (i) discriminating pathogenic and non-pathogenic lentiviral infections correlating with Aids progression as well (ii) in the context of parasitic infections such as leishmania, and more recently (iii) in the context of SARS-CoV-2 infection. They also demonstrated the role of death molecules (such as Fas/CD95 and its ligand, FasL) and of cysteine proteases (caspases). Thus, caspase inhibitors may represent immunomodulating agents by preventing the death as well inflammation.

In the context of intracellular pathogens, Estaquier’s team demonstrated the role of the mitochondria as a hub in controlling host-pathogen interactions. Thus, manipulation of host metabolic fluxes by pathogens represents immune escape strategies leading to long-term microbe survival and playing an important role in the pathology of infection. In this context, mitochondria dynamics was shown to be crucial in regulating mitochondria permeabilization and immune defense.

Thus, the team is in front the line for understanding PCD in the context of host-pathogen interactions proposing novel strategies to improve immune responses against microbes.

Top 5 publications

1. André S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butaux A, Soundaramourty C, Cruz AS, Mendes-Frias A, Gotti C, Leclercq M, Nicolas A, Tauzin A, Carvalho A, Capela C, Pedrosa J, Castro AG, Kundura L, Loubet P, Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Racine G, Zghidi-Abouzid O, Nioche P, Silvestre R, Droit A, Mammano F, Corbeau P, Estaquier J.
T cell apoptosis characterizes severe Covid-19 disease. 2022.
Cell Death Differ. 22: 1–14.

2. Mesquita I, Ferreira C, Moreira D, Kluck GEG, Barbosa AM, Torrado E, Dinis-Oliveira RJ, Gonçalves LG, Beauparlant CJ, Droit A, Berod L, Sparwasser T, Bodhale N, Saha B, Rodrigues F, Cunha C, Carvalho A, Castro AG, Estaquier J, Silvestre R.
The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. 2020.
Cell Rep. 30: 4052-4064.e7.

3. André S, Rodrigues V, Pemberton S, Laforge M, Fortier Y, Cordeiro-da-Silva A, MacDougall J, Estaquier J.
Antileishmanial Drugs Modulate IL-12 Expression and Inflammasome Activation in Primary Human Cells. 2020.
J Immunol. 204: 1869-1880.

4. Rabezanahary H, Moukambi F, Palesch D, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Tremblay C, Silvestri G, Estaquier J.
Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques. 2020.
Mucosal Immunol. 13: 149-160.

5. Laforge M, Silvestre R, Rodrigues V, Garibal J, Campillo-Gimenez L, Mouhamad S, Monceaux V, Cumont MC, Rabezanahary H, Pruvost A, Cordeiro-da-Silva A, Hurtrel B, Silvestri G, Senik A, Estaquier J.
The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques. 2018.
J Clin Invest. 128: 1627-1640.

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