Ciaran Condon

Sep 7, 2022

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Ciaran Condon

Institut de Biologie Physico-Chimique

RNA Maturation and Decay

condon@ibpc.fr

Website: http://www.ibpc.fr/UMR8261/AccueilEN/Theme%20CC/ThemeCC.html
ORCID: 0000-0002-2199-9621
Twitter: @condonlab

Our lab is interested in post-transcriptional gene regulation in the Gram-positive model bacterium Bacillus subtilis, in particular in phenomena that affect the rate of mRNA decay. We are interested in the identification of new ribonucleases, their mRNA and stable RNA substrates, and how they are regulated. We are also interested in small regulatory RNAs (sRNAs) and understanding how they can modulate mRNA decay rates either directly or indirectly (e.g. via translation). We use molecular genetics, molecular biology and structural approaches in most of our projects

 

Top 5 publications

1. Durand, S., Callan-Siddat, A., McKeown, J., Li, S., Kostova, G., Fernaud, J.R.H., Alam, M.T., Millard, A., Allouche, D., Constaninidou, C., Condon, C., and E.L. Denham (2021)
Novel regulation from novel interactions: Identification of an RNA sponge that controls the levels, processing and efficacy of the RoxS riboregulator of central metabolism in Bacillus subtilis.
Nucl. Acids Res. (49) 6399-6419 https://doi.org/10.1093/nar/gkab444

2. Oerum, S., Dendooven, T., Catala, M., Gilet, L., Dégut, C., Trinquier, A., Bourguet, M., Barraud, P., Cianferani, S., Ben F. Luisi, B. F.., Condon, C.* and C. Tisné*. (2020)
Structures of B. subtilis maturation RNases captured on 50S ribosome with pre-rRNAs.
Mol. Cell 80:227-236. * co-corresponding authors

3. Trinquier, A., Ulmer, JE., Gilet, L., Figaro, S., Hammann, P., Kuhn, L., Braun, F. and C. Condon (2019)
tRNA maturation defects lead to inhibition of rRNA processing via synthesis of pppGpp.
Mol. Cell. (74) 1227-1238.e3 doi.org/10.1016/j.molcel.2019.03.030

4. Braun, F., Durand S. and C. Condon (2017)
Initiating ribosomes and a 5’/3′-UTR interaction control ribonuclease action to tightly couple B. subtilis hbs mRNA stability with translation
Nucl. Acids Res. 45, 11386-11400. https://doi.org/10.1093/nar/gkx793

5. Leroy, M., Piton, J., Gilet, L., Pellegrini, O., Proux, C., Coppée, J-Y., Figaro, S. and C. Condon. (2017)
Rae1 (YacP), a new endoribonuclease involved in ribosome-dependent mRNA decay in B. subtilis.
EMBO. J. (36) 1167-1181 https://doi.org/10.15252/embj.201796540.

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