Caroline Demangel

Website: https://research.pasteur.fr/en/team/immunobiology-and-therapy/
ORCID: 0000-0001-7848-586X
Twitter: @Demangel_Lab

Studying infections to discover new bioactive compounds and therapeutic targets.

In the Pasteurian tradition, we are passionate about host-microbe interactions and their role in genesis of human diseases. Through the study of successfull pathogens, we aim to identifiy new means to manipulate the immune system and tackle cancer and infectious diseases. We have a particular knowledge of the immunosuppressive mechanisms evolved by mycobacteria. We also developed expertise in the immunometabolism of Hidradenitis Suppurativa, a chronic inflammatory skin disease associated with microbiome alterations. Our research is conducted at the molecular, cellular and whole organism levels in models of human disease, and it combines fundamental and translational studies.

Top 5 publications

1. Grotzke JE, Kozik P, Morel JD, Impens F, Pietrosemoli N, Cresswell P, Amigorena S, Demangel C (2017) Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of
   endosome-to-cytosol export. Proc Natl Acad Sci U S A, 114(29):E5910-E5919. PMID:28679634
2. Morel JD, Paatero AO, Wei J, Yewdell JW, Guenin-Macé L, Van Haver D, Impens F, Pietrosemoli N, Paavilainen VO, Demangel C (2018) Proteomics reveals scope of mycolactone-mediated Sec61
   blockade and distinctive stress signature. Mol Cell Proteomics. 17(9):1750-1765. PMID:29915147
3. Guenin-Macé L, Morel JD, Doisne JM, Schiavo A, Boulet L, Mayau V, Goncalves P, Duchatelet S, Hovnanian A, Bondet V, Duffy D, Ungeheuer MN, Delage M, Nassif A, Di Santo JP, Demangel C
   (2020) Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa. JCI Insight. 5(20):e140598. doi: 10.1172/jci.insight.140598.
4. Laval T, Pedró-Cos L, Malaga W, Guenin-Macé L, Pawlik A, Mayau V, Yahia-Cherbal H, Frigui W, Bertrand-Michel J, Guilhot C, Demangel C (2021) De novo synthesized polyunsaturated fatty
   acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis. 10:e71946. doi: 10.7554/eLife.71946.
5. Domenger A, Choisy C, Baron L, Mayau V, Deriano L, Arnulf B, Bories J.C., Dadaglio G, Demangel C (2021) The Sec61 translocon is a therapeutic vulnerability in multiple myeloma. EMBO Mol Med. 14(3):e14740. doi: 10.15252/emmm.202114740

Dernières publications sur HAL :