Sébastien Léon

Website: https://www.ijm.fr/research-topics/research-groups/leon-lab-va/?lang=en
ORCID: 0000-0002-2536-8595
Twitter: @SebLeon5

Our team seeks to determine the adaptation strategies of cells to nutritional stresses, such as nutrient deficiencies or inhibition of metabolism. Our work is at the intersection of cell biology, cell signaling and metabolism, using the yeast Saccharomyces cerevisiae as a model.

We have many tools and expertise to perform experiments in the field of protein localization, post-translational modifications, interactions, proteomics, genetic screens (including a RoToR Robot by Singer and several genome-wide collections) etc.

Top 5 publications

1. Laussel C, Albanèse V, García-Rodríguez FJ, Ballin A, Defenouillère Q, Léon S (2022)
2-deoxyglucose inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity.
bioRxiv 2022.03.29.486183; doi: https://doi.org/10.1101/2022.03.29.486183

2. Ivashov V, Zimmer J, Schwabl S, Kahlhofer J, Weys S, Gstir R, Jakschitz T, Kremser L, Bonn GK, Lindner H, Huber LA, Leon S, Schmidt O, Teis D.
Complementary alpha-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids.
eLife. 2020;9. doi: 10.7554/eLife.58246. PubMed PMID: 32744498.

3. Defenouillėre Q, Verraes A, Laussel C, Friedrich A, Schacherer J, Leon S.
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose.
Sci Signal. 2019;12(597):aaw8000. doi: 10.1126/scisignal.aaw8000. PubMed PMID: 31481524.

4. Hovsepian J, Albanese V, Becuwe M, Ivashov V, Teis D, Leon S.
The yeast arrestin-related protein Bul1 is a novel actor of glucose-induced endocytosis.
Mol Biol Cell. 2018;29(9):1012-20. doi: 10.1091/mbc.E17-07-0466. PubMed PMID: 29514933; PMCID: PMC5921569.

5. Hovsepian J, Defenouillere Q, Albanese V, Vachova L, Garcia C, Palkova Z, Leon S.
Multilevel regulation of an alpha-arrestin by glucose depletion controls hexose transporter endocytosis.
J Cell Biol. 2017;216(6):1811-31. Epub 2017/05/05. doi: 10.1083/jcb.201610094. PubMed PMID: 28468835; PMCID: PMC5461024.

Dernières publications sur HAL :