Website: http://www.ibpc.fr/UMR8261/AccueilEN/Theme%20CC/ThemeCC.html
ORCID: 0000-0002-2199-9621
Twitter: @condonlab
Our lab is interested in post-transcriptional gene regulation in the Gram-positive model bacterium Bacillus subtilis, in particular in phenomena that affect the rate of mRNA decay. We are interested in the identification of new ribonucleases, their mRNA and stable RNA substrates, and how they are regulated. We are also interested in small regulatory RNAs (sRNAs) and understanding how they can modulate mRNA decay rates either directly or indirectly (e.g. via translation). We use molecular genetics, molecular biology and structural approaches in most of our projects
Top 5 publications
1. Durand, S., Callan-Siddat, A., McKeown, J., Li, S., Kostova, G., Fernaud, J.R.H., Alam, M.T., Millard, A., Allouche, D., Constaninidou, C., Condon, C., and E.L. Denham (2021)
Novel regulation from novel interactions: Identification of an RNA sponge that controls the levels, processing and efficacy of the RoxS riboregulator of central metabolism in Bacillus subtilis.
Nucl. Acids Res. (49) 6399-6419 https://doi.org/10.1093/nar/gkab444
2. Oerum, S., Dendooven, T., Catala, M., Gilet, L., Dégut, C., Trinquier, A., Bourguet, M., Barraud, P., Cianferani, S., Ben F. Luisi, B. F.., Condon, C.* and C. Tisné*. (2020)
Structures of B. subtilis maturation RNases captured on 50S ribosome with pre-rRNAs.
Mol. Cell 80:227-236. * co-corresponding authors
3. Trinquier, A., Ulmer, JE., Gilet, L., Figaro, S., Hammann, P., Kuhn, L., Braun, F. and C. Condon (2019)
tRNA maturation defects lead to inhibition of rRNA processing via synthesis of pppGpp.
Mol. Cell. (74) 1227-1238.e3 doi.org/10.1016/j.molcel.2019.03.030
4. Braun, F., Durand S. and C. Condon (2017)
Initiating ribosomes and a 5’/3′-UTR interaction control ribonuclease action to tightly couple B. subtilis hbs mRNA stability with translation
Nucl. Acids Res. 45, 11386-11400. https://doi.org/10.1093/nar/gkx793
5. Leroy, M., Piton, J., Gilet, L., Pellegrini, O., Proux, C., Coppée, J-Y., Figaro, S. and C. Condon. (2017)
Rae1 (YacP), a new endoribonuclease involved in ribosome-dependent mRNA decay in B. subtilis.
EMBO. J. (36) 1167-1181 https://doi.org/10.15252/embj.201796540.
Dernières publications sur HAL :
- [hal-02171288] sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradationby ano.nymous@ccsd.cnrs.fr.invalid (Sylvain Durand) on 25 April 2024 at 22h35
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- [hal-04328824] Complex sporulation-specific expression of transcription termination factor Rho highlights its involvement in...by ano.nymous@ccsd.cnrs.fr.invalid (Vladimir Bidnenko) on 7 December 2023 at 11h58
Abstract Transcription termination factor Rho controls pervasive, mainly antisense, transcription initiated at cryptic signals or resulting from […]
- [hal-04279259] Shutdown of multidrug transporter bmrCD mRNA expression mediated by the ribosome-associated endoribonuclease...by ano.nymous@ccsd.cnrs.fr.invalid (Valentin Deves) on 10 November 2023 at 13h54
Rae1 is a well-conserved endoribonuclease among Gram-positive bacteria, cyanobacteria, and the chloroplasts of higher plants. We have previously […]
- [hal-04278788] Effect of tRNA Maturase Depletion on Levels and Stabilities of Ribosome Assembly Cofactor and Other mRNAs in...by ano.nymous@ccsd.cnrs.fr.invalid (Aude Trinquier) on 10 November 2023 at 11h02
The passage of ribosomes across individual mRNAs during translation can have different effects on their degradation, ranging from a protective effect […]