Guilhem Janbon

Website: https://research.pasteur.fr/fr/team/rna-biology-of-fungal-pathogens/
ORCID: 0000-0002-4788-1154
Twitter: @GuilhemJanbon

I lead the RNA Biology of Fungal Pathogens unit at the Institut Pasteur in Paris, France. The unit theme of research is centered on the study of the Cryptococcus transcriptome. Over the recent years, we have studied different aspects of the transcriptome structure and dynamic in these pathogenic yeasts. We have thus implemented several RNA sequencing strategies to construct very detailed and precise annotation of three references genomes. We have also been interested in the role of introns in the regulation of gene expression.  We also used this set of data to study the transcriptome plasticity including alternative splicing regulation and alternative TSS usage regulation.  More recently, we develop several project on extracellular vesicles studying of course the extracellular vesicles transcriptome but also their structure, diversity as well as their biosynthetic pathway, roles in drug resistance and virulence in pathogenic fungi.

Top 5 publications

1. Rizzo J., Wong, S.S.W., Gazi, A.D., Moyrand F., Chaze, T., Commere P-H., Novault, S., Matondo, M., Péhau-Arnaudet, G., Reis, F.C.G., Vos M., Alves, L.R., May, R.C., Nimrichter, L., Rodrigues, M.L., Aimanianda, V. & Janbon G. (2021) Cryptococcus extracellular vesicles properties and their use as vaccine platforms. Journal of Extracellular Vesicles 10:e12129

2. van Wijlick L & Janbon G (2021) Commensalism instead of sex? Adapting mating to live in the gut. Cell Host Microbe. 29:856-858. doi: 10.1016/j.chom.2021.05.001.

3. Maufrais C, de Oliveira L, Bastos RW, Moyrand F, Reis FCG, Valero C, Gimenez B, Josefowicz LJ, Goldman GH, Rodrigues ML & Janbon G. (2021) Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution. G3 (Bethesda) jkab107. doi: 10.1093/g3journal/jkab107. Online ahead of print.

4. Ferrareze P.A.G., Maufrais C., Silva Araujo Streit R., Priest S.J., Cuomo C., Heitman J. Staats C.C. & Janbon G. (2021) Application of an optimized annotation pipeline to the Cryptococcus deuterogattii genome reveals dynamic primary metabolic gene clusters and genomic impact of RNAi loss. G3 (Bethesda) 11.jkaa070. doi: 10.1093/g3journal/jkaa070.

5. Wallace E., Maufrais C., Sales-Lee J., Tuck L., de Oleivera L., Feuerbach F., Moyrand F., Natarajan P., Madhani H.D. & Janbon G. (2020) Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom. Nucleic Acids Research, 48(5):2312-2331

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