Carole Peyssonnaux

Website: https://institutcochin.fr/equipes/fer-immunite
ORCID: 0000-0002-1392-8225
Twitter: @peyssonnaux_lab 

1) Our team has a long standing expertise in the interplay between iron homeostasis and bacterial infection. Iron is an essential element for humans and other vertebrates, as well as for their microbial invaders. Therefore a “fight for iron” takes place between the host and the intruders. Innate immunity effectively restricts iron availability to microorganisms. On the other hand, some microbes have evolved effective countermeasures to blunt the effect of iron restriction.
Hepcidin, originally identified as a cationic antimicrobial peptide is now recognized as the key hormone produced by the liver maintaining systemic iron homeostasis in the organism. We showed that hepcidin is also produced in tissues that interface with the microbial environment, such as the skin and the intestine. In the skin, we recently found that epidermal hepcidin is required for neutrophil response to bacterial infection (Malerba et al., JCI, 2020). In the intestine, we demonstrated that hepcidin production by dendritic cells controls local iron bio-availability to shape the microbiota to promote mucosal healing, but promoting colonization with tissue protective microbes and inhibiting colonization with tissue infiltrating microbes (Bessman et al., Science, 2020).

2) We have expertise in subcutaneous infection models in mice. Generation of primary keratinocytes and bone marrow-derived macrophages.

Top 5 publications

1- Claise C, Saleh J, Rezek M, Vaulont S, Peyssonnaux C, Edeas M (2021).Low transferrin levels predict heightened inflammation in patients with COVID-19: New insights. Int J Infect Dis. 116:74-79.

2- Malerba M, Louis S, Cuvellier S, Mairpady Shambat S, Hua C, Gomart C, Ortonne N, Fouet A, Decousser J-W, Zinkernagel A, Mathieu J, Peyssonnaux C (2020). Epidermal hepcidin is required for neutrophil response to bacterial infection. Journal of Clinical Investigation. 130(1):329-334.

3- Bessman N.J., Mathieu J.R.R.*, Renassia C*, Zhou L, Fung T.C., Fernandez K.C., Austin C, Moeller J.B., Zumerle S, Louis S, Vaulont S, Ajami N.J., Sokol H., Putzel G.G., Arvedson T., Sockolow R.E., Lakhal-Littleon S., Cloonan S.M., Arora M, Peyssonnaux C*, Sonnenberg G.F*(co-last corresponding authors*) (2020). Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science. 368(6487):186-189.

4- Renassia C, Louis S, Cuvellier S, Boussetta N, Deschemin JC, Borderie D, Bailly K, Poupon J, Dang PM, El-Benna J, Manceau S, Lefrère F, Vaulont S, Peyssonnaux C (2020). Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed. Blood Adv. 4(16):3853-3863.

5- Zlatanova I, Pinto C, Bonnin P, Mathieu JRR, Bakker W, Vilar J, Lemitre M, Voehringer D, Vaulont S, Peyssonnaux C, Silvestre JS. (2019). Iron Regulator Hepcidin Impairs Macrophage-Dependent Cardiac Repair After Injury.  Circulation. 139(12):1530-1547.

Dernières publications sur HAL :