Sandra Duharcourt

Jul 13, 2022

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Sandra Duharcourt

Institut Jacques Monod, 15 rue Hélène Brion 75013 Paris

Epigenetic regulation of genome organization

sandra.duharcourt@ijm.fr

Website: https://www.ijm.fr/research-topics/research-groups/duharcourt-lab-va/?lang=en
ORCID: 0000-0002-8913-8799
Twitter: @DuharcourtLab

Our work aims to understand the fundamental mechanisms governing chromosome structure and genetic stability in eukaryotes. We study a remarkable process of genome editing that occurs during development in the unicellular eukaryote Paramecium.
Keywords: epigenetics, transposable elements, non-coding RNA, chromatin, Polycomb, genome evolution, Paramecium

 

Top 5 publications

1.Miró-Pina C, Charmant O, Kawaguchi T, Holoch D, Michaud A,  Cohen I, Humbert A, Jaszczyszyn Y,  Chevreux G, Del Maestro L, Ait-Si-Ali S, Arnaiz O, Margueron R, Duharcourt S. (2022) Paramecium Polycomb Repressive Complex 2 physically interacts with the small RNA binding PIWI protein to repress transposable elements. Dev Cell. 2022 Apr 6;S1534-5807(22)00208-8. doi: 10.1016/j.devcel.2022.03.014. PMID: 35429435

2.Gnan S#,  Matelot M#,  Weiman M, Arnaiz O, Guérin F, Sperling L, Bétermier M, Thermes C, Chen CL*, Duharcourt S*. (2022) GC content but not nucleosome positioning directly contributes to intron-splicing efficiency in Paramecium. Genome Res. 2022 Mar 9;gr.276125.121. doi: 10.1101/gr.276125.121. PMID: 35264448

3. Sellis S#, Guérin F#, Arnaiz O, Pett W, Lerat E, Boggetto N, Krenek S, Berendonk T, Couloux A, Aury J-M, Labadie K, Malinsky S, Bhullar S, Meyer E, Sperling L, Duret L*, Duharcourt S*. (2021). Massive colonization of protein-coding exons by selfish genetic elements in Paramecium germline genomes. PLoS Biol 19(7): e3001309. https://doi.org/10.1371/journal.pbio.3001309 PMID: 34324490

4. Vanssay A#, Touzeau A#, Arnaiz O, Frapporti A, Phipps J, Duharcourt S. (2020). The Parameciumhistone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements. PLoS Genet. 2020 Jul 23;16(7):e1008949. doi: 10.1371/journal.pgen.1008949. PMID: 32702045

5. Frapporti A#, Miró-Pina C#, Arnaiz O, Holoch D, Kawaguchi T, Humbert A, Eleftheriou E, Lombard B, Loew D, Sperling L, Guitot K, Margueron R, Duharcourt S. (2019). The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium. Nat Commun. 2019 Jun 20;10(1):2710. doi: 10.1038/s41467-019-10648-5. PMID: 31221974

 

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